{"id":15402,"date":"2026-05-15T15:38:15","date_gmt":"2026-05-15T06:38:15","guid":{"rendered":"https:\/\/www.iir.hit-u.ac.jp\/en\/?p=15402"},"modified":"2026-10-07T15:46:07","modified_gmt":"2026-10-07T06:46:07","slug":"results-20261007-7","status":"publish","type":"post","link":"https:\/\/www.iir.hit-u.ac.jp\/en\/2026\/05\/15\/results-20261007-7\/","title":{"rendered":"\u3010Tohru Yoshioka-Kobayashi\u3011Advancement in Cell and Gene Therapy Research: A 35-Year Bibliometric Perspective"},"content":{"rendered":"\t\t
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\u25b6<\/span>Category\uff1a<\/strong><\/span> Article<\/p>

\u25b6Author<\/strong><\/span><\/span>\uff1a<\/strong>Kitahara, Yuki\uff1aHiroaki Koda\uff1aJunya Kataoka\uff1aKumiko Tatsumi\uff1aRyo Nishino\uff1aTohru Yoshioka-Kobayashi\uff1aSumimasa Nagai
<\/span>
\u25b6<\/span>Institution\uff1a<\/strong>Cytotherapy<\/span><\/p>

\u25b6<\/span><\/span>Volume<\/strong>\uff1a<\/strong>Vol.28
<\/span>
\u25b6<\/span>Number\uff1a<\/strong>Issue 4<\/p>

\u25b6<\/span>Page\uff1a<\/strong>pp.1-11<\/p>

\u25b6<\/span><\/strong><\/span>Date\uff1a<\/strong>2026\/04\/01<\/span><\/p>

\u25b6Article Title<\/span><\/strong><\/span>\uff1a<\/strong>Advancement in Cell and Gene Therapy Research: A 35-Year Bibliometric Perspective<\/p>

\u25b6<\/span>Abstract\uff1a<\/strong>Cell and gene therapies (CGT) have been increasingly translated into clinical practice over the past three decades; however, their development has been uneven across modalities and regions. \u3010Methods\u3011 Through a bibliometric analysis indexed in PubMed from 1989 to 2023, supplemented by citation and affiliation data from OpenAlex, we examined modality-specific progression under different regional and collaborative configurations and how transitions from basic to clinical research have emerged. \u3010Results\u3011 Hematopoietic stem cell therapies have shown sustained growth in both clinical and high-impact publications, reflecting a mature field that remains scientifically relevant. In contrast, mesenchymal stem cell therapies experienced a rise in high-impact papers in the mid-2000s, but clinical publications stagnated, indicating a gap between academic interest and clinical applications. In gene therapy, the number of in vivo approaches increased in the 1990s. However, this was followed by a plateau in high-impact publications and a decline in clinical output, whereas ex vivo strategies have sharply increased since the mid-2010s, marking a transition toward tangible clinical translation. To further evaluate the global research landscape, we analyzed research activity and co-authorship patterns across countries and institutions in CGT. Our findings reveal distinct patterns of international collaboration. The United States and, more recently, China accounted for a large and growing share of CGT publications and high-impact papers, whereas Europe maintained steady contributions, and Japan’s presence stagnated. Higher-impact output is generally associated with broader cross-border co-authorship, especially collaborations linking the United States and Europe, whereas collaborations involving China and Japan remain comparatively narrow. \u3010Conclusions\u3011 These results provide a data-driven foundation for guiding research policies and strategic cooperation in this evolving field.
Notes<\/p>


\u25b6<\/span>Notes\uff1a<\/strong><\/p>

\u25b6<\/span>URL\uff1a<\/strong>https:\/\/www.sciencedirect.com\/science\/article\/pii\/S1465324926000125?via%3Dihub<\/span><\/a><\/p>

\u25b6<\/span>Register date\uff1a<\/strong>2026\/05\/15<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"

\u25b6Category\uff1a Article \u25b6Author\uff1aKitahara, Yuki\uff1aHiroaki Koda\uff1aJunya Kataoka\uff1aKumiko Tatsumi\uff1aRyo Nishino\uff1aTohru Yoshioka-Kobayashi\uff1aSumimasa Nagai \u25b6Institution\uff1aCytotherapy \u25b6Volume\uff1aVol.28 \u25b6Number\uff1aIssue 4 \u25b6Page\uff1app.1-11 \u25b6Date\uff1a2026\/04\/01 \u25b6Article Title\uff1aAdvancement in Cell and Gene Therapy Research: A 35-Year Bibliometric Perspective \u25b6Abstract\uff1aCell and gene therapies (CGT) have been increasingly translated into clinical practice over the past three decades; however, their development has been uneven across modalities and regions. \u3010Methods\u3011 Through a bibliometric analysis indexed in PubMed from 1989 to 2023, supplemented by citation and affiliation data from OpenAlex, we examined modality-specific progression under different regional and collaborative configurations and how transitions from basic to clinical research have emerged. \u3010Results\u3011 Hematopoietic stem cell therapies have shown sustained growth in both clinical and high-impact publications,…<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"sns_share_botton_hide":"","vkExUnit_sns_title":"","_vk_print_noindex":"","sitemap_hide":"","_veu_custom_css":"","veu_display_promotion_alert":"common","vkexunit_cta_each_option":"","footnotes":""},"categories":[62,61],"tags":[],"class_list":["post-15402","post","type-post","status-publish","format-standard","hentry","category-article","category-results"],"veu_head_title_object":{"title":"","add_site_title":""},"_links":{"self":[{"href":"https:\/\/www.iir.hit-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/15402","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.iir.hit-u.ac.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.iir.hit-u.ac.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.iir.hit-u.ac.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.iir.hit-u.ac.jp\/en\/wp-json\/wp\/v2\/comments?post=15402"}],"version-history":[{"count":8,"href":"https:\/\/www.iir.hit-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/15402\/revisions"}],"predecessor-version":[{"id":15415,"href":"https:\/\/www.iir.hit-u.ac.jp\/en\/wp-json\/wp\/v2\/posts\/15402\/revisions\/15415"}],"wp:attachment":[{"href":"https:\/\/www.iir.hit-u.ac.jp\/en\/wp-json\/wp\/v2\/media?parent=15402"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.iir.hit-u.ac.jp\/en\/wp-json\/wp\/v2\/categories?post=15402"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.iir.hit-u.ac.jp\/en\/wp-json\/wp\/v2\/tags?post=15402"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}